Instructions for use of sodium bicarbonate injection: The applicable groups of sodium bicarbonate injection include: i. Treatment of metabolic acidosis, for mild to moderate metabolic acidosis, oral administration is appropriate; for severe metabolic acidosis, intravenous drip should be given, including severe renal disease, circulatory failure, cardiopulmonary resuscitation, extracorporeal circulation and severe primary lactic acidosis, diabetic ketoacidosis, etc. Second, alkalinize urine, used for the prevention of uric acid kidney stones, reduce the nephrotoxicity of sulfonamides as well as acute hemolysis, and prevent hemoglobin deposition in the renal tubules. Third, as an acid control drug to treat symptoms caused by excessive stomach acid. IV. Intravenous drip has non-specific therapeutic effect on certain drug poisoning, such as barbiturates, salicylates and methanol poisoning. Dosage: The amount of alkaline supplementation for metabolic acidosis (mmol) = (-2.3 – actual measured BE value) × 0.25 × body weight (kg), usually give 1/3-1/2 of the calculated dose first, and titrate within 4-8 hours.