Indirect bilirubin is high for several years according to the causes of hepatocellular jaundice, hypersplenism and so on, and can be given medication such as glutathione, dicyclomol, ceftriaxone sodium, surgical treatment and so on. 1. Hepatocellular jaundice: Hepatocellular jaundice is caused by hepatocellular pathology which leads to the reduction of bilirubin uptake, conversion and excretion, and indirect bilirubin can be elevated, and the clinical manifestations include yellow coloration of the skin and mucous membranes and gastrointestinal tract symptoms, etc. It can be treated with glutathione, glycyrrhizinic acid preparation, bicyclic acid and other medications, and patients whose liver function is seriously impaired can be treated with liver transplantation surgery. 2. Hypersplenism: Hypersplenism can be caused by developmental abnormality or secondary to infection or immunity disease, which leads to excessive enhancement of spleen function, resulting in reduction of blood cells, proliferation of bone marrow hematopoietic cells, and elevation of indirect bilirubin. If it is caused by infection, you can give ceftriaxone sodium and other treatments, and if the condition is serious, you can have splenic embolization, splenectomy and other surgeries. Indirect bilirubin may also have other causes, it is recommended to go to the hospital in a timely manner, improve the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment or therapy. All of the above medications should be used under the guidance of a physician, and should not be used without authorization.