Although patients with drug-resistant tuberculosis are more difficult to treat and have a higher death rate, not all patients with drug-resistant tuberculosis are incurable, but the course of treatment needs to be extended. Therefore, patients with drug-resistant tuberculosis need to actively cooperate with doctors in treatment and pay attention to the following matters: 1. early diagnosis and early treatment: insist on early diagnosis and early medication, and insist on combined and regular medication, and choose the appropriate dose of therapeutic drugs; 2. monitoring for adverse reactions: as drug-resistant patients are usually resistant to isoniazid and rifampin, which are the mainstay drugs for treating tuberculosis. Once drug resistance occurs, it is necessary to switch to second-line anti-tuberculosis drugs, which usually have more adverse reactions than first-line ones, and some patients cannot tolerate them, so it is necessary to pay close attention to the occurrence of adverse reactions, and once there is discomfort, they should go to the hospital promptly; 3. The dosage of drugs should be adjusted in a timely manner according to the doctor’s instructions, and the occurrence of adverse reactions, such as biochemical, liver function and kidney function, should be monitored with the help of the doctor; 4. If you are not able to adhere to the full course of treatment and stop the drug prematurely, it will lead to a relapse of TB disease. If a one-time complete cure is not achieved, the difficulty of treatment will further increase after another relapse and the death rate will be higher. Therefore, patients with drug-resistant tuberculosis should increase their confidence in treatment, adhere to hospital visits, and follow the doctor’s instructions on medication to maximize the prognosis, and some patients can be cured.