The primary role of fisetin is for hemostasis, which can act on bleeding due to heparin overdose or spontaneous bleeding caused by other factors, such as massive vomiting and hemoptysis. For those who apply heparin during cardiovascular surgery, extracorporeal circulation or through continuous blood purification, such as hemodialysis or plasma exchange, fisetin can be applied to neutralize residual heparin in the body at the end of treatment. However, there are different degrees of adverse reactions to the use of fisetin, such as bradycardia, chest tightness, hypotension, dyspnea, and flushing of the face when applied too rapidly. The application of fisetin is not suitable for patients with allergy to the plasma protein layer for combined heparin therapy. If applied outside cardiac surgery, thrombocytopenia due to body circulation can be aggravated by thrombocytopenia after injection of large amounts of fisetin.