The nose is always sore and runny. It may be upper respiratory tract infection, acute rhinitis, allergic rhinitis, acute sinusitis and so on. 1. Upper respiratory tract infection: upper respiratory tract infection is mainly related to viral and bacterial infections, and patients will experience symptoms such as sore nose, sneezing, runny nose, nasal congestion, dry throat, fever, cough and other discomforts. 2. Acute rhinitis: it is mainly caused by respiratory viruses such as rhinovirus and adenovirus, and can also be secondary to bacterial infection. When the pathogen causes irritation to the nasal tissues, it can be manifested as old sour and runny nose. Some patients with acute rhinitis are also prone to nasal dryness, foreign body sensation, nasal congestion, sneezing and other symptoms. 3. Allergic rhinitis: Allergic rhinitis is related to genetic factors and exposure to allergic substances. Patients can also be irritated by allergic substances in the nose and appear always sour, runny nose symptoms, but also easy to be accompanied by nasal itching, paroxysmal sneezing, nasal congestion, tearing, coughing and other uncomfortable symptoms. 4. Acute sinusitis: sinusitis is related to pathogen infection, which can also cause the nose is always sour, runny nose. Some sinusitis patients are also prone to chills, fever, loss of appetite, nasal congestion, headache, mental instability, memory loss and other symptoms. It is recommended to consult a doctor in time for examination in order to clarify the cause of the disease and then follow the doctor’s instructions for treatment.