Equine Fang Syndrome, also known as spider finger (toe) syndrome, is a congenital inherited connective tissue disorder that is inherited in an autosomal dominant fashion. It mainly affects the skeletal, ocular, cardiovascular and nervous systems. The national prevalence is about 0.02%, and the prevalence is equal in both sexes. The pathology of the systemic lesion of Mafang syndrome is mainly cystic necrosis of the middle layer of the aortic root, destruction of smooth muscle, abnormal collagen fibers, reduction, degeneration and rupture of elastic fibers, replaced by scar tissue and mucus material, resulting in thinning of the aortic mesothelium, reduction of the elasticity and strength of the arterial wall, and gradual expansion of the aorta over time, resulting in aortic aneurysm. Cystic necrosis of the middle layer of the aorta and the mechanical impact of blood cause endocardial tearing, and blood enters the middle layer of the aorta, dividing the vessel wall into two layers and forming a hematoma and intercalated aneurysm. The hematoma can expand to the periphery and increase the peeling area of the vessel wall. It can invade the aortic valve proximally and also involve the distal aortic arch and descending aorta, and its prevalent sites are mostly in areas with strong blood flow impact. The main ultrasound manifestations are aneurysmal dilatation of the ascending aorta and dilatation of the aortic sinuses, and color multispectral imaging of multiple red-blue flows in the ascending aorta with regurgitation. In the presence of a coarctation aneurysm, the aortic wall shows two separated echogenic bands, and the dilated aortic lumen is floated with slender bands of strong echogenicity as an avulsed intima, dividing the lumen into true and false lumen. A colorful mosaic of diastolic regurgitant bundles appears in the left ventricular outflow tract and is accompanied by enlargement of the left ventricle with increased ventricular wall motion, but diminished in the event of heart failure. The main danger of this disease is cardiovascular changes, which should be detected and treated early, and the easiest and most effective means to diagnose this disease is echocardiography. Echocardiography can clearly show the morphological changes of ascending aorta, aortic valve and mitral valve, and clarify the site, scope and type of aortic coarctation; multispectral echocardiography can accurately and rapidly detect the abnormal blood flow caused by the lesion, distinguish the true cavity of the coarctation from the false cavity, clarify whether there is thrombus formation in the false cavity, and accurately determine the location of the rupture, which is the preferred imaging diagnostic method.