Marfan’s syndrome, also known as spider finger (toe) syndrome, is a congenital inherited connective tissue disorder that is autosomal dominant and has a family history. The lesions mainly involve the bones, heart, muscles, ligaments and connective tissues of the mesoderm. Skeletal deformities are most common, with elongated tubular bones throughout the body and elongated fingers and toes in the form of spider feet. The heart may have incomplete or prolapsed mitral valve and incomplete aortic valve. In the eye, there may be crystal subluxation and retinal detachment. In the cardiovascular area, the aorta or common abdominal aorta may be dilated and form aortic aneurysm or common abdominal aortic aneurysm. After a certain degree of aortic dilatation, it will cause death by aortic mega-rupture. The incidence is about 0.04‰ to 0.1‰. What are the clinical manifestations of Marfan’s syndrome? 1, the skeletal muscle system: mainly have long and thin limbs, spider fingers (toes), arms flat finger distance is greater than the length of the body, hands sagging over the knee, the lower half of the body than the upper half of the body is longer. Long head deformity, narrow face, high palatal arch, large and low ears. Little subcutaneous fat, underdeveloped muscles, wrinkled skin on the chest, abdomen and arms. The muscle tone is low, and the body is weak. Ligaments, tendons and joint capsules are elongated and lax, and joints are hyperextended. Sometimes funnel chest, chicken chest, kyphosis, scoliosis, spina bifida, etc. are seen. 2. Eyes: mainly crystalline subluxation or subluxation, high myopia, cataract, retinal detachment, iris tremor, etc. There are more males than females. 3.Cardiovascular system: about 80% of patients have congenital cardiovascular malformations. Progressive aortic dilatation, aortic valve closure insufficiency, aortic sinus aneurysm due to cystic necrosis of the middle layer of the aorta, intercalated aneurysm and rupture are common. Mitral valve prolapse and mitral valve insufficiency are also important manifestations of this syndrome. It can be combined with congenital atrial septal defect, ventricular septal defect, tetralogy of Fallot, patent ductus arteriosus, and aortic constriction. It can also be combined with various arrhythmias such as conduction block, pre-excitation syndrome, atrial fibrillation, atrial flutter, etc. How is Marfan’s syndrome diagnosed and treated? The main risk of Marfan’s syndrome is cardiovascular lesions, especially the combined aortic aneurysm, which should be detected and treated early. The diagnosis can be made based on the clinical presentation of the three main signs of skeletal, ocular and cardiovascular changes and family history. There are two clinical types: those with all three signs are called complete; those with only two signs are called incomplete. The easiest way to diagnose the disease is by echocardiography, which is available for all those who suspect it, and MRI (magnetic resonance imaging) for further confirmation. There is no specific treatment available. Early surgical repair of congenital cardiovascular lesions is recommended, while medical treatment is recommended for cardiac insufficiency and arrhythmias. Once diagnosed with a combined aortic aneurysm or heart valve closure insufficiency, surgical treatment should be considered as appropriate, as drugs cannot remove this disease. Because of the risk of rupture and bleeding from the aneurysm and the risk of death from heart failure from an insufficiently closed heart valve, experts recommend surgery despite the risks involved. In fact, with technological advances, the success rate of surgery is now above 90%. If a ruptured aortic coarctation aneurysm is indicated, surgery should be performed promptly.