The “RevisedGhentcriteria” is the latest version of the current international diagnostic criteria for Marfan syndrome, which was published in the internationally renowned JMedGenet journal in 2010. Its main contents are as follows: i. Marfan syndrome can be diagnosed in patients without family history who satisfy any of the following conditions 1. Aortic root Z score ≥ 2, lens ectasia, and exclusion of Sphrintzene-Goldberg syndrome, Loeyse-Dietz syndrome and vascular Ehlerse-Danlos syndrome and other similar disorders; 2. Z score ≥ 2 and pathogenic FBN1 gene mutation detected; 3. Aortic root Z score ≥ 2, systemic score ≥ 7 and exclusion of Sphrintzene-Goldberg syndrome, Loeyse-Dietz syndrome and vascular Ehlerse-Danlos syndrome and other similar disorders; 4. Lens ectasia and detection of aortic lesion-associated mutations in the FBN1 gene; ii. A family history of Marfan syndrome is diagnosed in patients with any of the following conditions 5. lens ectasia and a family history of Marfan syndrome; 6. a systemic score ≥ 7, a family history of Marfan syndrome, and exclusion of Sphrintzene-Goldberg syndrome, Loeyse-Dietz syndrome, and vascular Ehlerse-Danlos syndrome and other similar disorders; 7. Aortic root Z score ≥ 2 (over 20 years of age) or ≥ 3 (under 20 years of age), with a family history of Marfan syndrome and exclusion of Sphrintzene-Goldberg syndrome, Loeyse-Dietz syndrome and vascular Ehlerse-Danlos syndrome and other similar diseases. Note: (1) “Aortic root Z score” is a way to evaluate the degree of aortic root dilatation, the higher the score, the more severe the aortic root dilatation; (2) “Systemic score” is a way to comprehensively evaluate the characteristic symptoms of Marfan syndrome exhibited by all organs and systems of the body. (2) “System score” is a way to comprehensively evaluate the characteristic symptoms of Marfan syndrome in all organs and systems of the body, with a total score of 20 points, and a score of 7 points is considered to have diagnostic reference value (scoring points include: 3 points for both finger and wrist signs (1 point for only one of them), 2 points for chicken chest, 1 point for funnel chest, 2 points for heel deformity (1 point for flat foot), 2 points for history of pneumothorax, 2 points for dural dilatation, 2 points for acetabular protrusion, 2 points for decreased upper/lower volume, increased arm length/height and no (1 point for scoliosis, 1 point for scoliosis or kyphosis, 1 point for facial signs, 1 point for abnormal skin tags, 1 point for myopia greater than 300 degrees, and 1 point for mitral valve prolapse). Translated from: LoeysBL,DietzHC,BravermanAC,etal.TherevisedGhentnosologyfortheMarfansyndrome.JMedGenet.2010Jul;47(7):476-85