Non-variable factors: family history, race, age, male, reduced kidney size, congenital nephropathy, cystic kidney disease, glomerulosclerosis, menopause, etc. Variable factors: diabetes, hypertension, proteinuria, autoimmune disease, atherosclerosis, infection, ingestion of nephrotoxic drugs, uremic toxins, hypercoagulable state, hyperlipidemia, tubulointerstitial disease, anemia, smoking, obesity, post-renal obstruction, malnutrition, etc. We hope that the general public will avoid themselves from occurring or being exposed to various variables in their daily lives to protect their kidneys.