Blood creatinine 175μmol/L, urine protein 2+ can be divided into physiological and pathologic, physiological includes strenuous exercise, consuming a lot of meat, etc. Pathologic includes membranous nephropathy, IgA nephropathy, diabetic nephropathy and so on. 1. Physiological: blood creatinine and urine protein will increase after strenuous exercise, consuming large amount of meat or high protein food, and will return to normal after rest and diet control. 2. Pathologic: including membranous nephropathy, IgA nephropathy, diabetic nephropathy and so on. Membranous nephropathy is a group of diseases characterized by the deposition of immune complexes on the outside of the glomerular basement membrane and under the epithelial cells with the thickening of the glomerular basement membrane, which can be manifested as nephrotic syndrome. IgA nephropathy is a chronic glomerulonephritis caused by abnormal deposition of immunoglobulin A in the glomerular thylakoid zone, pathologically manifested as thylakoid hyperplasia, deposition of immune complexes in the thylakoid zone mainly with IgA, and hematuria and proteinuria as the main clinical manifestations, and the patients already have renal hypoplasia when they are diagnosed. Diabetic nephropathy is a microangiopathy caused by diabetes mellitus, which is one of the common causes of chronic kidney disease. If there is an increase in creatinine level and positive urine protein, you should go to the clinic in time to get a clear cause and timely treatment under the guidance of professional physicians.