The cause of myotonic dystrophy is a defect in the genes needed for the muscles to perform their functions. Therefore, only partial or complete correction of the genetic defects can treat the root of the disease. Research on gene therapy is still emerging and we believe that it will bring us surprises in the near future. However, for now, we still need to rely on other medications to slow down the disease progression to a certain extent. For DMD, the status of oral hormone therapy has been established and has been emphasized many times before. Comprehensive therapeutic measures such as physical therapy, adjuvant devices, and cardiopulmonary skeletal therapy are also beneficial to patient survival and quality of life. Some of the adjuvant therapeutic drugs that are widely used abroad for myotonic dystrophy are presented here. Although these drugs or food supplements do not have significant therapeutic effects like oral hormones, they are safe and reliable, have few side effects in long-term use, and have well-documented benefits for patients with myotonic dystrophy. 1. Creatine (creatine monohydrate): Creatine is the main energy supply molecule for muscles. It is mainly derived from lean meat and fish. Intensive supplementation reduces oxidative stress in muscle tissue, reduces calcium in-flow and myofiber apoptosis, thereby increasing muscle volume. Creatine is a food supplement taken daily by professional and amateur athletes and is among the drugs permitted for long-term use by the International Olympic Committee and other sports organizations due to its natural origin and excellent safety profile. There are good studies on the use of creatine in patients with muscular dystrophy. A systematic summary and analysis of the results of these studies, the authoritative Cochrane, concludes that high-quality evidence from randomized controlled clinical trials suggests that creatine therapy improves muscle strength and motor function in patients with muscular dystrophy in the short to medium term. Creatine was well tolerated in treated patients. The dose of creatine needs to be adjusted according to the specific case, and inappropriate use may cause liver, kidney and heart damage. In addition, since creatine promotes the transfer of water to muscle tissue, care needs to be taken to drink more water. At the same time, because water is gathered in the muscles, it may make weight gain. 2, L-arginine: Arginine is one of the twenty essential amino acids, mainly from lean meat, fish and dairy products. Intensive supplementation helps regulate immune function and improve muscle blood supply. It has been confirmed that arginine is one of the main substrates for the synthesis of nitric oxide in the body. And nitric oxide is the most important vasodilator molecule in the body. In muscle, nitric oxide requires the production of nitric oxide synthase anchored to Dystrophin. When Dystrophin is partially or completely absent, nitric oxide synthase is also dramatically reduced and cannot ensure the large blood supply required for muscle contraction. This is one of the widely recognized pathogenic mechanisms of DMD/BMD in recent years. The ongoing clinical trials of PDE5 inhibitors are guided by this theory. Therefore, in addition to its broad effects, L-arginine supplementation may play a role in DMD disease delay from this mechanism. Other applications of L-arginine include adjunctive therapy for angina pectoris, hypertension, hyperemesis, lower extremity arterial ischemia, renal disease, and to accelerate wound healing. It is not generally used in patients with hypotension due to its ability to mildly lower blood pressure. Caution is also needed in patients who have had herpes, which may cause a recurrence of the herpes virus. The dose of L-arginine should be taken under the guidance of a physician and should be monitored for kidney function. 3. Coenzyme Q10: Coenzyme Q10 is an important delivery substrate for mitochondrial energy metabolism and is derived from meat and seafood. Intensive supplementation helps to improve energy metabolism, reduce oxidative stress, maintain heart function and enhance immunity. As a drug and food supplement, coenzyme Q10 is widely used in a variety of diseases such as heart failure, hypertension, diabetic peripheral neuropathy, neurodegenerative diseases, migraines, AIDS, and myotonic dystrophy. In addition to focusing on protecting the heart, some studies have shown that taking coenzyme Q10, even on top of oral hormone therapy, can further improve limb movement. Discomforts that may be caused by coenzyme Q10 include stomach upset, loss of appetite, nausea, diarrhea and lower blood pressure, and some people have had allergic skin reactions. The likelihood of these discomforts will be significantly reduced if once-daily dosing is changed to two to three times daily. In addition to adjusting the dosing method, individual dosing varies and requires physician guidance and follow-up observation.