Hand skin wrinkles, may be related to normal physiological phenomena, age, hand eczema, etc., can be targeted to the use of hand care or topical drugs and other means to improve. 1. Normal physiological phenomenon: after the hands are wet, the skin absorbs water and forms a wrinkled appearance. This situation does not need special treatment, will recover on its own. 2. Age: the metabolism of the elderly body slows down, the body’s water loss will lead to the appearance of skin wrinkles, especially the back of the hand skin. You can rub hand cream with moisturizing effect, such as allantoin cream. 3. Hand eczema: Hand eczema is an inflammatory skin disease caused by internal and external factors that can cause damage to the skin barrier of the hands, which can be manifested as dry, flaky or rough hands. Avoid contact with irritants, strengthen hand moisturizing, can be used externally hydrocortisone cream and other glucocorticoid cream to control inflammation. If the skin on the hands is wrinkled, go to the hospital and follow the doctor’s instructions for appropriate treatment.