Mild magnesium sulfate poisoning can occur when too much magnesium sulfate injection is used, and the patient will have self-conscious fever, flushing, nausea, vomiting, muscle aches and pains, fatigue, dizziness, and accompanied by obvious symptoms of irritation and pain at the injection site. In severe cases, there will also be motor nerve paralysis, loss of tendon reflexes, respiratory depression, prolonged conduction time, and cardiac arrhythmia. If the above situation occurs, it should be alert to the patient’s serious magnesium sulfate poisoning, at this time, it is necessary to give treatment quickly, and it can be applied to calcium gluconate injection intravenously. In addition, if the patient injects magnesium sulfate overdose, for example, obvious nausea, vomiting and so on, the patient has a generalized muscle tone, respiratory difficulty, respiratory muscle paralysis and so on, need to quickly open the respiratory access, give tracheal intubation and other emergency measures.