The callus on the sole of the foot is painful and hard, which may be caused by callus, corns, viral warts and so on. It is recommended to reduce the friction stimulation, drug treatment, if necessary, consider surgical excision treatment. 1. callus: callus is commonly known as callus, and local long-term pressure and friction, resulting in keratin hyperplasia, hardening, is a keratinized skin damage. In the early stage, you can soak your feet in warm water, and use urea ointment, salicylic acid ointment, vitamin A cream, etc., which can remove excess keratin and relieve pain. 2. Corns: Corns are related to the long-term extrusion and friction of the local skin, resulting in localized yellowish or dark-yellow limited keratinous growths and obvious pain when pressed. It is recommended to choose the right size, soft and hard shoes, and use corns cream externally, and remove them completely through surgery if necessary. 3. Viral warts: Viral warts on the soles of the feet are usually caused by human papilloma virus infection, resulting in local warts. They can be treated with topical retinoic acid cream, imiquimod cream, or by liquid freezing. The calluses on the soles of the feet are hard and painful, and it is recommended to pay attention to daily care, reduce friction and extrusion, and go to the dermatology department of the hospital for diagnosis and treatment if necessary.