Thyroglobulin antibody is a common autoantibody in the serum of patients with autoimmune thyroid disease. It is of clinical value in the regression and treatment of thyroiditis, especially Hashimoto’s thyroiditis. In Hashimoto’s thyroiditis with hypothyroidism, symptoms such as malaise, constipation, bradycardia, or no symptoms may be present. Elevated thyroglobulin antibodies are common in autoimmune thyroid diseases such as Hashimoto’s thyroiditis and Graves’ disease. Both Hashimoto’s thyroiditis and Graves’ disease may present with symptoms of goiter. Patients with Hashimoto’s thyroiditis may have symptoms of hypothyroidism, such as weight gain, bradycardia, malaise, decreased concentration, and constipation. Patients with Graves’ disease may have symptoms of hyperthyroidism, such as tachycardia, weight loss, bulging eyes, excessive sweating, fear of heat, agitation, and irritability. Some patients may also have no obvious symptoms in the early stages of the disease. It is advisable to consult a doctor to determine the presence of elevated thyroglobulin antibodies, rather than making a blind judgment on your own.