The number of years that one can live with lipofuscinosis depends on the specific case. In mild cases, the symptoms do not affect the life expectancy, while in severe cases, the life expectancy can range from a few months to several years due to the involvement of organs. Lipofuscinosis can be divided into systemic lipofuscinosis and cutaneous lipofuscinosis, depending on the site of involvement. The life expectancy of systemic lipofuscinosis cannot be predicted due to individual differences in body composition and severity of the disease. In mild cases, most of them are curable and do not affect life expectancy. In patients with lipofuscinosis with significant organ involvement, long-term medications are required to control the disease and prevent organ damage, and the patient’s life expectancy may be only a few months to a few years. In conclusion, the prognosis for dermatolipiditis is generally good, with an 85% chance of living 20 years or more with early diagnosis and treatment, adherence to treatment, and regular checkups until the rash is no longer present, but patients should also prevent complications.