Perifollicular keratosis is generally referred to as perifollicular keratosis, a condition that generally requires no treatment; patients with significant symptoms or who require treatment may improve with topical and oral medications. Perifollicular keratosis is a chronic follicular keratotic skin disease with some genetic predisposition, which typically manifests as follicular keratin plugs or keratinized papules consistent with pores. Keratosis pilaris is usually not harmful to human health and only affects aesthetics, so patients do not need to go untreated. Patients with treatment needs may use topical 1% retinoic acid cream, 3%~5% salicylic acid ointment, 10%~20% urea cream, or 10%~20% cod liver oil ointment to soften or dissolve keratin and improve symptoms. Serious patients can take oral retinoids, etc. The use of oral medications should be in strict accordance with the doctor’s instructions to prevent drug-induced liver function abnormalities and other adverse reactions. It is recommended that patients with keratosis pilaris go to the hospital in time, under the guidance of the doctor to carry out standardized treatment, if there is a need for treatment need to strictly comply with the doctor’s instructions for the use of drugs.