Thoracic sympathectomy is a classic procedure for the treatment of hand sweating, but the incidence of compensatory hyperhidrosis after surgery can be as high as 85%, with severe compensatory hyperhidrosis occurring in about 15% of cases, which has become a major factor in patients’ reduced satisfaction with the procedure and regret of undergoing it. Various methods have been tried abroad to treat compensatory hyperhidrosis, such as oral gastric longing, botulinum toxin injections, and even the use of nerve grafts and transcutaneous electrical stimulation, but none of them have achieved definite long-term results. We designed the sympathetic modulation treatment for compensatory hyperhidrosis: by injecting a small amount of neuromodulator under the precise guidance of CT to denature some nerve fibers to effectively inhibit the excessive activity of the sympathetic nerve chain without destroying the anatomical structure of the nerve chain, we achieve both the inhibition of its excessive sweating and the preservation of its normal sweating function under high temperature and heat. A safe, effective, minimally invasive and economical treatment for compensatory hyperhidrosis has been found. The hospital stay is only 3-4 days and the results can be observed immediately after treatment.