Mirtazapine can be combined with venlafaxine. Mirtazapine combined with venlafaxine is more effective than venlafaxine alone in treating depression, and is safe, effective, and well tolerated in treating somatoform pain disorder. Mirtazapine is a norepinephrine and pentazocine antidepressant, it is more obvious to improve the sleep disorder and appetite decline in patients with depressive disorders, and rarely cause sexual dysfunction, suitable for elderly patients with insomnia disorder and anxiety symptoms of depression. Venlafaxine belongs to the selective pentazocine and norepinephrine reuptake inhibitor, high dose also has an inhibitory effect on dopamine uptake, the efficacy of this drug is related to the dose, along with the dose increases, the efficacy of the increase, the adverse effects also increased. The combination of these two drugs in patients with refractory depression is effective and can help patients regain cognitive ability. Adverse effects such as nausea, withdrawal syndrome, and sexual dysfunction are common with venlafaxine and are contraindicated in patients with a history of allergy to the drug. Mirtazapine is commonly associated with excessive sedation, weight gain, dry mouth, and increased appetite, and is contraindicated in patients with allergies and granulocyte deficiency. Therefore, it is necessary to use under the guidance of a doctor, not unauthorized use of drugs.