[Abstract] Objective To evaluate the value of OMOM capsule endoscopy for the diagnosis of unexplained gastrointestinal bleeding Methods Sixty-three patients were clearly identified as having unexplained gastrointestinal bleeding, and the OMOM capsule endoscopy system of Chongqing Jinshan Company Technology Group was used for examination and summary analysis: results Among 63 patients, lesions were detected in 52 cases, with a positive detection rate of 82.5%. Among them, 19 cases (30.1%) were small intestinal vascular lesions; 19 cases (30.1%) were small intestinal tumors; 7 cases (11.1%) were small intestinal ulcers (including Crohn’s disease); 3 cases (4.7%) were small intestinal diverticula; 2 cases (3.1%) were small intestinal active bleeding; 1 case (1.5%) was duodenal bulb ulcer; 1 case (1.5%) was hookworm disease; 1 case (1.5%) was small intestinal vascular malformation combined with hookworm disease ( 1.5%). Conclusion: OMOM capsule endoscopy is safe, simple to operate, and has good patient compliance, and its detection rate of unexplained gastrointestinal bleeding is high, so it can be used as an important screening tool for unexplained gastrointestinal bleeding. Unexplained GI bleeding refers to persistent or recurrent GI bleeding in which the source of bleeding cannot be determined by conventional GI endoscopy (including gastroscopy from the esophagus to the descending duodenum and colonoscopy from the anorectum to the end of the ileum). Before 2001, studies of unexplained gastrointestinal bleeding were lacking because of the difficulty of complete examination of the small intestine, but with the introduction of capsule endoscopy, complete observation of the small intestinal mucosa has been possible, which has greatly improved the diagnosis rate of unexplained gastrointestinal bleeding [1]. In this paper, we summarize the results of 63 cases of unexplained gastrointestinal bleeding examined by capsule endoscopy in our department from August 2008 to August 2010, and evaluate the value of capsule endoscopy in the diagnosis of small bowel diseases.