Valsartan may cause ankle swelling, and angioedema has been reported with valsartan. Valsartan is a nonpeptide angiotensin II (ATII) receptor blocking drug. These drugs selectively block ATII receptor subtype I (AT1) receptors, and angioedema may occur as a side effect of AT1 receptor blocking drugs when taken orally. Angioedema often occurs in the more sparse areas of subcutaneous tissue or mucous membranes, presenting as a limited transient large swelling with indistinct margins, not itchy, and usually involves the eyelids, lips, tongue, external genital organs, hands, and feet, with the ankles being the most common part of the feet. At present, the mechanism of its occurrence may be: valsartan into the body, bradykinin and other vasoactive peptides are activated, resulting in angioedema, in addition to valsartan as a non-immune substance into the body can stimulate mast cells to release histamine and other vasoactive substances, resulting in angioedema. If patients experience swelling of the ankles during the administration of valsartan, care should be taken to identify whether it is drug-induced edema, and patients are advised to consult a physician and not to judge for themselves. Valsartan is contraindicated in patients with severe hepatic and renal impairment and in patients who are allergic to the product. Specific drug use should be under the guidance of a physician.