The clinical DPT and pentavalent rotavirus vaccines are two completely different vaccines, and the specific differences are reflected in the types of diseases prevented and the timing of vaccination. Both DPT and pentavalent rotavirus vaccines belong to the national class II vaccines, so for infants and children who have a vaccination plan, parents can choose the appropriate vaccination according to their personal situation.1. Types of diseases to be prevented: DPT is a mixed vaccine, which is a combination of inactivated polio vaccine, acellular diphtheria vaccine, and Haemophilus influenzae type B vaccine, and can prevent pertussis, diphtheria, tetanus, polio, and Haemophilus influenzae type B vaccine at the same time. It is a combination of inactivated polio vaccine, acellular pertussis vaccine, and Haemophilus influenzae type B vaccine. The pentavalent rotavirus vaccine is a vaccine containing five strains of bovine rotavirus (G1, G2, G3, G4, and G9), which only aims to prevent rotavirus infection; 2. Vaccination time: The pentavalent vaccine is usually completed at 3 months, 4 months, and 5 months after birth for the three basic immunizations. When the infant is 1.5 years old, a booster vaccination will be given, so the pentavalent vaccine is four doses in total. The first dose of pentavalent rotavirus vaccine is usually given at 6 weeks of age, the second dose at 10 weeks of age, and the third dose at 14 weeks of age, requiring a total of three injections; 3. Method of vaccination: The pentavalent vaccine is administered by intramuscular injection, while the pentavalent rotavirus vaccine is an oral preparation; 4. Other: The protection rate of pentavalent vaccine is close to 100%, and the protection rate of pentavalent rotavirus vaccine against five viruses is about 95%. The pentavalent vaccine is indicated for infants and children over 2 months of age, while the pentavalent rotavirus vaccine is indicated for infants and children between 6 and 32 weeks of age.