Changes in crying: low or moaning cries, or shrill cries, or paroxysmal crying and restlessness with pallor. Difficulty in breastfeeding: weak sucking, not eating milk or reducing the amount of milk eaten by half of the usual amount. Fever or temperature does not rise: fever above 38.5℃, or body temperature below 35.5℃ (not rising after 1 hour of insulation). Skin bruising and hard swelling: bruising is more obvious in nose, lips, tongue and pharynx, and hard swelling is obvious in lower limbs, buttocks and cheeks. Convulsions (tics): eye gaze, localized muscle and limb twitching or generalized convulsions. Respiratory abnormalities: obvious chest depression during inhalation with exhalation, utterance of utterance of moan, apnea, or increase in respiratory rate ≥60 breaths/min or slowing down.