Dry syndrome is a chronic autoimmune disease that invades exocrine glands, especially salivary glands and lacrimal glands. The main manifestation is dryness of the mouth and eyes, but there may also be multi-organ and multi-system damage, such as interstitial lung fibrosis and renal tubular acidosis. There is a large infiltration of lymphocytes in the affected organs and the serum is positive for various autoantibodies. There are primary and secondary syndromes, which often overlap with other rheumatic immune diseases. At present, the purpose of treatment for primary dry syndrome is mainly to relieve the patient’s symptoms, stop the development of the disease and prolong the survival period of the patient, and there is no method to cure the disease. The treatment for primary dry syndrome is not only to relieve the patient’s symptoms of dry mouth and eyes, but more importantly to terminate or inhibit the abnormal immune reaction occurring in the patient’s body, protect the patient’s organ function and reduce the occurrence of lymphoma. Treatment includes three levels: 1. saliva and tear replacement therapy to improve symptoms; 2. enhancing the residual function of exocrine glands to stimulate saliva and tear secretion; 3. systemic medication to change the immunopathological process of patients and finally protect the function of patients’ exocrine glands and organs. General treatment: take proper rest, ensure sufficient sleep, avoid overwork, quit smoking and drinking, maintain certain humidity indoors and prevent upper respiratory tract infection. Treatment of dry keratitis: using 0.5% methylcellulose drops to form artificial tears can relieve symptoms and prevent ocular complications in about 50% of patients. In patients with partially preserved lacrimal function, occlusion of the nasolacrimal duct by electrocoagulation can allow limited tear accumulation and relieve dryness. Cortisone ophthalmic ointment has the potential to promote corneal ulcer perforation and should be avoided. Treatment of oral dryness: liquid can be used to moisten the oral cavity to relieve symptoms; oral saliva reduction is prone to infection, common candida infection, local use of mycobacterium. Pay attention to oral hygiene and regular dental checkups can help prevent or delay the occurrence of dental caries. If the saliva of parotid gland decreases, purulent parotitis may occur and antibiotics should be applied early. Treatment of other dry symptoms: nasal dryness can be treated with saline nose drops, do not use lubricants containing oil, so as not to cause lipoid pneumonia by inhalation, dry skin generally does not require treatment, sweating reduced, the heat should be prevented from high heat stroke. Systemic treatment: Hormones and immunosuppressants such as hydroxychloroquine and biological agents can be used; the advantages and disadvantages of drugs should be noted. Hormone: Hormone therapy should be avoided in those with stable disease, and those with various combined connective tissue diseases are indications for hormone application. Prednisone 30-40mg/d can be used orally in divided doses, and the dose will be reduced after remission, and the hormone should be withdrawn as early as possible. Immunosuppressants: commonly used are hydroxychloroquine, cyclophosphamide (CTX), azathioprine, etc. Hydroxychloroquine 200-400mg/d, CTX 100-200mg/d (adults), azathioprine 100-200mg/d (adults). If maintenance therapy is required after remission, the minimum maintenance dose should be selected. Immunosuppressive agents may be added or switched when the disease is not effective with hormones. Biological agents: Abnormal activity of auto-reactive B cells is one of the important factors in the pathogenesis of SS. Anti-CD20 and anti-CD22 antibodies for B cell clearance can improve SS.