When it comes to dry syndrome (abbreviation: SS), many people feel unfamiliar with this disease name, which is called by modern western medicine, but Chinese medicine called it “dryness disease” more than two thousand years ago. Dry syndrome is a disease with dry eyes, dry nose, and dry mouth as the main symptoms, but the cause is unknown. This autoimmune disease, which is based on lymphocyte infiltration and exocrine gland lesions, can often lead to multiple organ damage. In Chinese medicine, it is thought to be caused by endowment intolerance, imbalance of qi and blood in the internal organs, blood deficiency and blood stasis, loss of lung qi, and inability to distribute water and fluid in all directions, resulting in various dry manifestations such as dry skin, dry mouth, dry nose, and dry eyes. There is also evidence of yin deficiency and fire, which is caused by yin deficiency or external heat and dryness. Although this disease is multi-symptomatic and difficult to treat, compared with SLE, the degree of harm and treatment difficulty of dry syndrome are less than that of SLE. Below I will briefly introduce some general manifestations of this disease. Modern medicine divides dry syndrome into primary and secondary. Primary syndrome refers to the specific symptoms of dry syndrome alone, without the clinical manifestations of other autoimmune diseases; secondary syndrome refers to the clinical manifestations of dryness secondary to other autoimmune diseases as the basis of pathogenesis. The primary desiccation syndrome is described in this article. Clinical manifestations of desiccation syndrome: (a) Eye symptoms The occurrence of dry keratitis due to atrophy of lacrimal gland and reduction of tear secretion is the characteristic manifestation of this disease. This disease is commonly seen in dry eyes, eye fatigue, eye pain, red eyes, blurred vision or foreign body sensation. In about 50% of patients, there is a significant decrease in tears. Due to the reduction of tears can not sterilize self-cleaning and make the eye vulnerable to the erosion of bacteria, mold, viruses and other harmful microorganisms. (B) Oral symptoms Oral dryness varies in severity, with the heaviest cases unable to eat cookies, buns and bread. Due to the decrease of saliva, the self-cleaning ability of the mouth is reduced, and the axial surface of the teeth is powdered or small pieces are easily broken and fall off, and the remaining roots of the teeth are called “rampant caries”. Some patients have oral ulcers and cracked corners of the mouth, or have alternately swollen parotid glands on both sides and changed parotid gland shape. （About 2/3 of patients have non-erosive arthritis, and half of patients have rheumatoid arthritis. (iv) Nasal and respiratory symptoms There are varying degrees of dryness in the nasal cavity, poor sense of smell, and persistent hoarseness in some patients. Chronic bronchitis, pulmonary atelectasis. Interstitial pulmonary fibrosis may occur in patients with long-term hormone use. (E) Gastrointestinal symptoms Difficulty in swallowing due to reduced secretion of glands in the esophagus and pharynx, and susceptibility to chronic atrophic gastritis. Constipation due to reduced intestinal fluid. (vi) Hepatobiliary symptoms Nearly half of the patients develop hepatomegaly, chronic active hepatitis, and biliary cirrhosis. (vii) Pancreatic symptoms Acute and chronic recurrent pancreatitis can occur in about 10% of patients. (H) Renal symptoms Due to the metabolic imbalance of the secretory function, resulting in renal tubular atrophy, decreased renal tubular function and reduced water absorption, dehydration, thirst or amino acid urine, diabetes, hypokalemia, high blood nitrogen, renal tubular acidosis. (ix) Laboratory tests Mild anemia and leukopenia occur in about 1/3 of patients; most patients have accelerated sedimentation, hypergammaglobulinemia, and positive rheumatoid factor; half of patients are positive for ANA antibodies; 2/3 of patients are positive for SS-A antibodies and half are positive for SS-B antibodies. The age of onset of dry syndrome is mostly in female patients over 40 years old, and as they age, the secretory function decreases while the immune function is instead hyperactive, leading to excessive production of antibodies by multiple cells while injuring the metabolic function of the secretory system. This vicious circle pattern is inevitably the result of the involvement of glands such as the lacrimal, salivary, parotid and pancreatic glands. It is because the cause of dry syndrome is due to self-injurious hyperimmune function, so it is confirmed that this disease is an autoimmune disease. In addition, the clinical symptoms of dry syndrome are often accompanied in other diseases, such as rheumatoid arthritis, systemic lupus erythematosus, periarteritis nodosa, systemic scleroderma, hyperglobulinemic purpura, Hashimoto’s thyroiditis, vasculitis, primary biliary cirrhosis, chronic active hepatitis and other diseases may have the clinical manifestations of dry syndrome. In the authors’ opinion, it is surprising that clinical symptoms of dry syndrome can exist in so many and complicated diseases, which makes the etiology and pathogenesis of dry syndrome more confusing. One symptom can appear in many diseases, and a group of symptoms can also appear in many diseases. Is there a distinction and significance between primary and secondary for this disease, is the understanding of this disease too vague, and is there any practical role for guiding clinical treatment? It should be re-examined to avoid the embarrassing situation that clinical medicine is always in a state of helplessness for the treatment of this disease. This is because this disease is a disease for which hormone therapy is prohibited. Why the level of Chinese medicine treatment of this disease is far ahead, that is the principle of Chinese medicine Qiheng’s internal organs in the practice of identification and treatment clearly understand and can grasp the evidence of the disease or the disease of the evidence. One pathogenic state produces different manifestations in the patient, or multiple diseases can have the same clinical manifestation. The authors must emphasize that according to the immune principle of Qi Heng’s internal organs is the relationship between the brain, the veins, and the woman’s cells, which are also the main evidence of the lungs, spleen, and kidneys among the five organs. In clinical practice most doctors use the method of nourishing Yin and omit the rule of administering the treatment of invigorating blood and opening the ligaments as the main. This disease is often seen in more than 60% of patients with dark tongue and greasy coating, and dry mouth without thirst. This is not evidence of Yin deficiency. For the understanding of “water and fluid cannot be distributed in all directions” in Chinese medicine, it means that the “dryness” of dry syndrome is not equal to Yin deficiency, but is caused by blood deficiency and blood stasis or stagnation of Qi deficiency and blood stasis. Therefore, try to cautiously use the products that nourish Yin and hinder the spleen, so as to avoid the disadvantage of deficiency without tonic. Based on the immune principle of Qi Heng’s internal organs, the author developed “Shuang Hu Sheng Jin Wan” not to nourish Yin and produce Jin, but to invigorate Blood and promote the flow of Blood and produce Jin. On the other hand, the products of invigorating blood and resolving blood stasis can accelerate the removal (metabolism) of immune complexes and promote the decline of antibodies. The clinical effect is very satisfactory. For the few patients with red tongue and little or no moss, the treatment is naturally satisfactory when supplemented with nourishing Yin products such as turtle nail, peony, raw earth and yellow essence, which are properly identified and treated.