A low albumin-to-globulin ratio may be due to liver or kidney disease, as well as rheumatologic and immunologic diseases.
Generally speaking, the ratio of albumin to globulin in the human body is (1.5~2.5):1, and when it is less than 1.5, it is considered as a low white globulin ratio.
A low albumin-to-globulin ratio may be characterized by a decrease in albumin, which is mainly due to decreased hepatic synthesis as a result of liver disease or loss of albumin via the urine as a result of kidney disease.
It can also be caused by an increase in globulin, which is seen in rheumatologic diseases such as rheumatoid arthritis, which can cause an abnormal increase in globulin synthesis and lead to a low white globulin ratio.
There may be other reasons for low white globule ratio. It is recommended to further improve CT and other imaging as well as immunological examination to clarify the etiology of the disease and receive standardized diagnosis and treatment.