Penile tie ulcers are considered to be caused by circumcision glans, penile tuberculosis, penile cancer and other diseases. 1. Inflammation of prepuce and glans: the causes of this disease are complicated and diverse, which can be divided into infectious and non-infectious (such as autoimmune diseases, trauma, etc.), after the disease, the patient’s prepuce, glans, penile ligament will appear red, swollen, burning pain and other symptoms, and in severe cases, ulcers, vesiculation, and even bleeding can also occur. 2. Penile tuberculosis: it is a disease caused by erosion of penis by tuberculosis mycobacterium. After the onset of the disease, there will be nodules or chronic ulcers on the glans head of the patient, and with the development of the disease, nodules or ulcers will be formed on the patient’s penis and penile girdle. 3. Penile cancer: the cause of the disease is still unclear, related to prepuce, HPV virus infection, etc. Penile cancer patients will have pimples or plaques on the head of penis, coronary groove, prepuce, penile ligament and other places, with the progress of the disease, the lesions can be developed into ulcers or cauliflower-like tumors. In addition, there are many other reasons that can cause penile tethered ulcers, so patients are advised to go to the hospital in time, clarify the cause of the disease and receive treatment as early as possible.