Patients with indwelling needle infections should have their needles removed in a timely manner and then be treated with anti-infective therapy. In the clinic, if the patients with indwelling needles have indwelling needle infections, the first need to pull out the indwelling needle, and then do a good job of bacterial examination and culture of the indwelling needle, and finally is to symptomatic treatment, do a good job of clinical care. Patients with indwelling needle infection should use magnesium sulfate to apply wet compresses to the local area, and indwelling needle infection is mostly caused by Staphylococcus aureus infection, which should be orally or intravenously applied with antibacterial drugs, such as amoxicillin, cefaclor antibiotics, etc., under the guidance of doctors. In severe cases, it is also necessary to incise and drain, and intravenous antibiotic treatment with ceftriaxone sodium, levofloxacin and other antibiotics in order to facilitate the recovery of the condition. Patients who develop indwelling needle infections should inform their doctors of any discomfort and seek early treatment.