If a patient has heart discomfort in the middle of the night, the condition may be due to resting angina or spasm of the coronary arteries, and the patient is advised to first measure the heart rate and blood pressure and preferably have an electrocardiogram. If the patient’s blood pressure is normal and his heart rate is fast, he can also take oral metoprolol or bisoprolol in combination. If the patient’s symptoms do not improve significantly after medication, he should go to the emergency room in time to perform cardiac enzymes and further electrocardiogram to see if there is a dynamic evolution of the current electrocardiogram.