Irbesartan and nifedipine can be taken orally at the same time to increase the effect of lowering blood pressure, and usually 1 tablet of each can be taken in combination. The main effect of Irbesartan is to reduce angiotensin production by inhibiting angiotensin II receptors, and its main indication is hypertension. Nifedipine dilates peripheral blood vessels by inhibiting calcium in-flow, and its main indications are hypertension and coronary artery disease. For patients with poor blood pressure control, Irbesartan and Nifedipine can be used together to achieve synergistic antihypertensive effect, usually take 1 tablet each, for patients with unsatisfactory blood pressure control, the dose can be adjusted again under the guidance of a doctor. Irbesartan adverse reactions include dizziness and headache, nausea and vomiting, muscle pain, edema, etc. Irbesartan is contraindicated in patients who are allergic to the drug components, pregnant and lactating women, or patients with severe renal insufficiency. Adverse reactions to nifedipine include lower extremity edema, dry stools, tachycardia, flushing, etc. It is contraindicated in patients with allergy to drug components, severe aortic stenosis, hypotension, and patients taking rifampicin. Clinical use of Irbesartan and nifedipine to lower blood pressure should be used under the guidance of a physician to choose the appropriate dose and method of use.