Advanced uremia can be treated by surgical treatment and blood purification treatment. 1. Surgical treatment: Kidney transplantation is the best renal replacement therapy at present. Successful kidney transplant can fully restore kidney function, including endocrine and metabolic function. Compared with dialysis, patients have better quality of life, lower maintenance cost and higher survival rate. 2. Blood purification therapy: Blood purification therapy can replace the kidneys to remove excessive substances and fluids from the body, mainly including hemodialysis and peritoneal dialysis. They have their own advantages and disadvantages and complement each other clinically. However, dialysis therapy can only partially replace the excretory function of the kidneys, but not its endocrine and metabolic functions. Patients who start dialysis need to actively correct renal hypertension and renal anemia. Patients with uremia are advised to go to regular hospitals in time and choose the appropriate treatment plan under the guidance of doctors.