Toothache is alert to diseases such as pulpitis, apical periapical inflammation, pericoronitis, occult fracture of teeth, etc. It may also be caused by maxillary sinusitis, osteomyelitis, trigeminal neuralgia or heart disease, etc. It is recommended to go to the hospital for timely examination and treatment. 1. The manifestation of persistent severe pain and spontaneous pain in the teeth may be due to inflammation of the nerve of the teeth, which is also known as pulpitis. 2. Teeth with occlusal pain and apical swelling may be apical periodontitis. 3. A partially erupted tooth with redness, swelling and pus around the gums may be pericoronitis. 4. Painful chewing and cracking of the teeth may be cryptocleidosis. 5. There are bulging cheeks and leakage of air, severe pain in the maxillary back teeth but no carious inflammation of the teeth may be maxillary sinusitis. 6. Multiple teeth loosening radiographs to check the jawbone large inflammation may be osteomyelitis. 7. Trigeminal neuralgia patients, there will be cheeks, upper and lower jaw and tongue obvious severe electric shock-like, needle-like, cut-like or tear-like pain, lasting a few seconds or 1 ~ 2 minutes, sudden sudden stop, in the corners of the mouth, nose, cheeks, or tongue and so on a certain part of the light touch can be induced (trigger point). 8. In patients with heart disease, when angina pectoris or myocardial infarction occurs, the pain may radiate to the jaw, and the patient may be infected with toothache, which is easily misdiagnosed if the pain in the precordial area is not obvious. Toothache may also have other causes, it is recommended to go to the hospital in time to identify the cause of the disease and timely treatment.