In Parkinson’s disease treatment, there are many Parkinson’s disease patients who say they get fatigued easily and that this fatigue is different from the fatigue they used to feel after occasional exertion when they did not have the disease; it is a constant and difficult fatigue that can be relieved by rest. Fatigue is the most common non-motor symptom of Parkinson’s disease Among the common non-motor symptoms of Parkinson’s disease, the most common is not loss of smell, constipation, or depression, but fatigue. In a survey of Italian Parkinson’s disease patients, it was found that 98.6% of 1072 patients had at least 1 non-motor symptom, and the incidence increased with the duration and severity of the disease. The common non-motor symptoms of Parkinson’s disease were, in order: fatigue (58%), anxiety (56%), lower extremity pain (38%), insomnia (37%), urinary urgency and nocturia (35%), salivation and difficulty in maintaining concentration (31%). Fatigue is therefore the most common non-motor symptom of Parkinson’s disease. How does Parkinson’s disease fatigue occur? It is not clear, but 66.7% of PD patients with fatigue believe that the nature of the fatigue they feel is different from that before they had Parkinson’s disease, suggesting that PD fatigue is produced differently than in the healthy population. Fatigue can occur prior to the onset of motor symptoms in PD patients, so the mechanisms by which fatigue occurs may be different from those of motor disorders. Parkinson’s disease is characterized by a decrease in nigrostriatal dopaminergic neurons, so many speculate that fatigue in Parkinson’s disease may also be related to dopamine depletion. The abnormal excitability of cortical motor neuron cells comes into play. Physical fatigue is not associated with mental fatigue in Parkinson’s disease, and it is speculated that the two may occur relatively independently of each other. Fatigue in Parkinson’s disease patients may be related to a lesion in a specific area of the brain or may be the result of a superposition of multiple pathophysiological processes. How to relieve fatigue in Parkinson’s disease The mechanisms by which fatigue occurs are not yet clear, thus contributing to the lack of specificity in current treatment. Evidence-based guidelines for the treatment of PD fatigue are also lacking internationally. Studies published in recent years on the treatment of PD fatigue have involved compounded levodopa, dopamine agonists, resagiline, memantine, caffeine, modafinil, phenylpiperidine methyl acetate, doxepin, behavioral interventions, exercise, etc. Among the drugs, only phenylpiperidine methyl acetate and resagiline significantly improved fatigue scores in PD patients. Antidepressants help to relieve depression-related fatigue, mental fatigue, etc. Treatments to improve sleep can improve physical fatigue and mental fatigue. Moderate physical activity can improve fatigue in many patients with chronic diseases, and it is indeed clinically possible to observe that fatigue can be reduced in some fatigued PD patients after appropriate activity. Patients are encouraged to walk or perform other similar activities for at least 30 minutes a day, or start with moderate exercise for 5 minutes 2-3 times a day to gradually increase tolerance.