High serum LDL cholesterol is mainly treated with lifestyle interventions as well as medications. Elevated serum LDL cholesterol levels are closely associated with the development of atherosclerotic diseases such as coronary heart disease and cerebral infarction. For patients with elevated LDL cholesterol levels, lifestyle intervention is usually the first step, which includes avoiding oily and high-salt diets, maintaining an appropriate frequency of aerobic exercise, quitting smoking and drinking, and maintaining adequate rest. Patients who do not respond well to lifestyle interventions and who have risk factors such as high blood pressure and diabetes usually need to be treated with medications. Commonly used medications include statins such as atorvastatin, cholesterol absorption inhibitors such as ezetimibe, and PCSK9 inhibitors such as iloyumab. Consult your doctor before taking any medication. Patients with high serum LDL cholesterol are advised to consult a doctor for advice and treatment.