The causes of acute myeloid leukemia include exposure to chemical causative agents, exposure to physical causative agents, hereditary disorders and gene mutations, and other prior hematologic disorders. Acute myeloid leukemia is a malignant tumor of the blood system. The cause of AML has not been determined by the medical profession, but may be related to the following factors. 1. Exposure to chemical pathogenic substances: including some anti-tumor drugs, some organic solvents, chloramphenicol, nitrosamines, harmful gases and other substances. 2. Exposure to physical pathogenic substances: including ionizing radiation, electromagnetic pollution and so on. 3. Factors of hereditary diseases and gene mutation: including Down’s syndrome, gene mutation, chromosome abnormality, etc. 4. Previously suffered from other hematologic diseases: other hematologic diseases may be transformed into AML, such as high-risk myelodysplastic syndromes. Clinical manifestations of acute myeloid leukemia include anemia, bleeding, infection, general weakness, sternal pain at the beginning of the disease, enlarged liver, spleen and lymph nodes. Once the above manifestations occur, it is necessary to go to the hospital in a timely manner in order to clarify whether there is acute myeloid leukemia, early diagnosis and early treatment.