The target symptom for treatment is determined, i.e., the symptom that has the greatest impact on the child’s daily life, learning or social activities, usually the tic symptom, while the target symptom for treatment of some children is the symptom of co-morbidities, such as hyperactive impulsivity, compulsive ideas, etc. Principles of treatment: Concurrent medication and psychotherapy, with attention to individualization of treatment. 1.Pharmacological treatment: 1.Preferred drugs: thiopride, aripiprazole, colistin, etc. Start from the lowest dose and gradually increase the dose slowly (1-2 weeks) to the target therapeutic dose. 2.Intensive treatment: after the disease is basically controlled, continue the treatment dose for 1-3 months. 3.Maintenance treatment: After the disease is controlled, maintain the treatment for 6-12 months, the maintenance dose is usually 1/2~2/3 of the treatment dose. 4.Discontinuation: After the maintenance treatment phase, the disease is completely controlled, gradually reduce and stop the drug, the reduction period is at least 1~3 months. If the symptoms recur or worsen, resume the medication or increase the dose. 5. Combined medication: If a single medication cannot be controlled, or if there is co-morbidity, consider combined medication; refractory tic disorder requires combined medication. Non-pharmacological treatment 1. Psycho-behavioral treatment: not overly concerned, reasonable arrangement of daily life. Behavioral treatment methods: habit reversal training, exposure and response prevention, relaxation training, cognitive behavioral therapy, positive reinforcement, fading exercises, etc. 2. Neuromodulation therapy: repetitive transcranial magnetic stimulation, electroencephalographic biofeedback and transcranial microcurrent stimulation, etc. Treatment of co-morbidities 1. Co-morbidities of ADHD: colistin, tomoxetine, or regular amount of dopamine receptor blockers with small dose stimulants. 2, co-occurrence of other behavioral disorders: such as learning difficulties, obsessive-compulsive disorders, sleep disorders, mood disorders, self-injurious behavior, conduct disorders, etc., should be taken to education and training, psychological intervention, joint medication, etc., and timely referral.