Tic disorders mostly manifest as blinking, frowning, nose shrugging, mouth tilting, head shaking, head nodding, shoulder shrugging, hand and foot shaking, twisting, vocalization, and obscene speech, and are often misdiagnosed as ADHD, conjunctivitis, pharyngitis, hypocalcemia, epilepsy, and chorea. Some studies have shown that tic disorders are misdiagnosed as ADHD the most often. There are 2 main reasons why it is often misdiagnosed as ADHD. 1, the concept is blurred: ADHD in addition to naughty, inattentive and impulsive, but also can show deliberate strange image or shouting and other tics, and nearly half of the children with tics can be accompanied by hyperactivity, coupled with the similarity of the two disease names, so often confuse the two very different diseases. 2, unfamiliar with the clinical manifestations and characteristics of ADHD: the core of ADHD is excessive activity, attention deficit, capricious impulsivity, while the core of tic disorder is muscle group twitching, often mistaking the increased frequency of twitching disorder for ADHD in daily life, and the simultaneous existence of the two is a lack of awareness, but also can not distinguish between the priorities. Cases misdiagnosed as conjunctivitis are in children with simple blinking or with blinking as the first symptom. In chronic conjunctivitis, blinking may occur as a symptom of eye irritation, but it is not the sudden, rapid, recurrent eye muscle twitching that is the main cause of twitch disorder, along with conjunctival congestion, vascular blurring, papillomatous hyperplasia, follicularity, and ocular pain and itching that are not present in TD. The cases misdiagnosed as pharyngitis were all children with simple vocal twitching, and the duration of the disease was more than 1 month, and repeated chest and pharyngeal examinations were normal. In addition to the above characteristics, the vocal tics were often short and high-pitched and loud, with a sense of deliberate amplification, not a real cough, and recurrent for a long time, with ineffective anti-inflammatory treatment, very different from the cough and pharyngeal inflammatory manifestations of pharyngitis. The cases misdiagnosed as hypocalcemic convulsions were mainly those with early onset head, face, and limb twitching in younger children, and the misdiagnosis was apparently related to unfamiliarity with the sudden, rapid, recurrent, and isolated motor seizures of TD. Cases misdiagnosed as epilepsy are mainly confused with partial motor seizures or myoclonic seizures. TD seizures have a developmental pattern, mostly starting with blinking, progressing in waves, and gradually progressing to the whole body. In contrast, most of the seizure forms are more fixed and the number of seizures is far less than that of TD. EEG is an important basis for differentiation. To prevent misdiagnosis, the first thing to understand is the characteristics of tic disorder tics in children: seizures are rapid, disappear instantly, can be triggered by mental stress, fatigue, cold and aggravated, and symptoms are reduced or disappear during sleep. The symptoms are often characterized by fluctuations in severity, and some of these children are accompanied by hyperactivity. Secondly, we call on society, especially school teachers and parents, to pay attention to children’s mental health education, reduce children’s psychological burden, strengthen health education, let teachers and parents understand the knowledge of tic disorder, do not scold and reprimand children for twitching, and keep affected children in a comfortable mood. Finally, it is extremely important to improve the awareness and diagnosis of the disease to reduce misdiagnosis. Clinicians should strengthen the professional knowledge related to tic disorders, broaden the diagnostic thinking, and grasp the characteristics of the disease in which there are multiple motor tics and one or more vocal tics in the course of the disease. Overcome the deficiency of narrow diagnostic thinking and neglect the horizontal connection of professional knowledge in various disciplines, and carefully observe cases, ask about related medical history and symptomatic manifestations, and make comprehensive analysis of the condition. Improve the level of diagnosis and treatment of psychoneurological diseases by lay physicians and primary care workers to avoid misdiagnosis and missed diagnosis.