The drugs that protect the myocardium include angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists, angiotensin receptor-enkephalinase inhibitors, and aldosterone receptor antagonists. All of these drugs inhibit the renin-angiotensin-aldosterone system, which can inhibit myocardial remodeling, protect the myocardium, and improve patient prognosis. Angiotensin-converting enzyme inhibitors are represented by drugs such as captopril, enalapril, and benazepril. Representative drugs of angiotensin II receptor antagonists, are crosartan, valsartan, irbesartan, and telmisartan. Representative drugs of angiotensin receptor-enkephalinase inhibitors, are sakubatril valsartan. Aldosterone receptor antagonists are represented by spironolactone and eplerenone. β-receptor antagonists protect the myocardium and improve patient prognosis by inhibiting sympathetic activation, and are represented by metoprolol, bisoprolol, and carvedilol.