Bleeding in the stool after taking aspirin enteric-coated tablets is considered to be caused by gastrointestinal bleeding due to the side effects of the drug, and it is recommended that the patient stop taking the drug in time and seek medical attention. Aspirin enteric-coated tablets will inhibit platelet aggregation, affecting the patient’s coagulation function, will cause gastrointestinal reactions to the direct stimulation of the gastric mucosa, such as nausea, vomiting, epigastric discomfort or pain, and long-term or high-dose can have gastrointestinal bleeding or ulcers, and in severe cases, bleeding in the stool may occur, which are the side effects of the drug. Patients need to stop taking the drug immediately, as well as visit the doctor to further improve the relevant tests, such as coagulation function, gastroenteroscopy to comprehensive assessment and judgment. If necessary, follow the doctor’s instructions to choose oral drugs, such as omeprazole, can inhibit gastric acid secretion, reduce the stimulation of gastric mucosa, reduce bleeding. To summarize, it is recommended that the patient consult a doctor in a timely manner, the doctor to give targeted treatment, do not blindly self-medication.