Calluses and dead skin on the hands can be removed by scraping with a knife, applying drugs or laser. 1. Scrape with a knife: you can soak your hands in warm water for a period of time every day to soften the local cuticle, and then gently scrape off the cuticle of the callus area with a sterilized knife to achieve the effect of removal. 2. Apply drugs: you can use salicylic acid cream, vitamin A cream and other keratolytic agents under the guidance of the doctor, these drugs have the role of softening the keratin, so that the hands of the callus and dead skin off. 3. Laser: you can stimulate the skin through the laser method, can make collagen regeneration, improve skin growth, so as to achieve the effect of removing calluses and dead skin on the hands. Daily attention should be paid to reduce hand friction, can improve the skin condition. It is recommended that patients with calluses and dead skin on the hands go to the hospital in time, under the guidance of the doctor to remove, not their own indiscriminate use of drugs, so as not to cause adverse consequences.