1. Pain in the retrosternal or precordial region, or tightness-like pain, radiating to the left shoulder or left upper arm, lasting 3-5 minutes, occurs with exertion or stress. 2, Chest tightness, palpitations, shortness of breath with physical activity, relieved by rest 3, Exercise-related headache, toothache, leg pain. 4, Chest pain and palpitation when full, cold or watching a thriller. 5, need to sleep with high pillow position; lying down suddenly chest pain, palpitation, dyspnea, need to sit up or stand up immediately can be relieved. 6. Panic, chest tightness and other discomforts when having sex or defecation difficulties. 7. Panic and chest tightness when listening to noise. Repeated irregular pulse, unexplained tachycardia or bradycardia.