High lactate in newborns, i.e. high lactate in the blood, is usually due to circulatory disorders, hypoxic diseases and inborn genetic metabolic disorders, and requires prompt medical attention when detected. If the newborn is in septic shock or has a severe infection, circulatory disturbances may lead to increased lactate. Secondly, lactate is often elevated when the newborn has a hypoxic condition, which often occurs during the prenatal period or at birth. A history of asphyxia and hypoxia in the newborn, such as ischemic-hypoxic encephalopathy or severe pneumonia, can lead to hypoxia and elevated lactate. In addition, the presence of inborn genetic metabolic disorders, especially disorders of amino acid metabolism, usually leads to increased lactate. It is recommended that newborns with high lactate be seen by a doctor to determine the cause of the condition and to have it managed or treated.