After the 2nd recurrence of cerebral infarction, aggressive treatment should be given. If the onset time is more than 3 months according to the 1st onset time, thrombolysis can be considered if there are indications for thrombolysis and no contraindications. If thrombolysis is not suitable, aspirin against platelet aggregation can be given, and clopidogrel can also be given. Neuroprotective therapy is also given, and the commonly used drugs are cytarabine, olacitant, piracetam, and edaravone. Treatment to improve blood circulation may be given, and the main drugs used are sulforaphane, vincristine, and trimethoprim. If the patient is suffering from cerebral embolism due to atrial fibrillation, anticoagulation therapy can be given. The main drugs commonly used are low molecular heparin. Patients may also be given butylphthalide therapy to improve the signs and symptoms of neurological deficits, mainly for patients with more severe disease. If the patient has severe somatic signs and symptoms, rehabilitation therapy should be given 48-72 hours after stabilization to reduce the signs and symptoms of neurological deficits and prevent sequelae.