High-grade gliomas are low-differentiated gliomas, which are malignant tumors. Recurrent high-grade glioma needs to be treated with surgery, medication, radiotherapy and chemotherapy again according to the specific situation.
1. Surgery: For patients with recurrent high-grade glioma, surgery, such as tumor resection, may be needed again.
2. Drug treatment: If the patient has cerebral edema, it is necessary to apply mannitol, glucocorticoid dehydration and lowering cranial pressure according to the doctor’s instruction. If accompanied by epileptic seizures, patients should follow the doctor’s instructions to apply sodium valproate, oxcarbazepine and other anti-epileptic drugs.
3. Radiotherapy: For recurrent high-grade glioma, radiotherapy should be chosen after evaluating the specific situation of the patient, and generally radiotherapy should be started 2~6 weeks after surgery.
4. Chemotherapy: chemotherapy should be taken as early as possible after surgery. At present, temozolomide is the chemotherapeutic drug with clear efficacy in the treatment of glioma. Other chemotherapeutic drugs, such as Nimustine, may have certain efficacy in the treatment of recurrent glioma. Some patients are prone to adverse reactions such as bone marrow suppression and gastrointestinal discomfort after chemotherapy. The medication should be administered in strict accordance with the doctor’s prescription.
5. General measures: when in the hospital, patients should closely monitor the vital signs, eat a light diet and take regular rest.
Once recurrence occurs, patients should go to the hospital for consultation and active treatment.