Different patients have different sensitivities to drugs, levofloxacin, amoxicillin for cholecystitis does not exist which is better, the general use of the two together better. Levofloxacin is a quinolone, amoxicillin is a penicillin, both belong to the broad-spectrum antibiotics. Cholecystitis is mostly caused by gallbladder stones, resulting in a bacterial infection of the gallbladder. Amoxicillin has a slight promotion of bile excretion, but also has an anti-inflammatory and bactericidal effect, while levofloxacin has a good antibacterial effect, the patient’s different body sensitivity to the drug is different, the effect will also be different. When the effect of levofloxacin and amoxicillin alone is not good, they can be applied in combination to have better anti-inflammatory effect. Before using the above drugs, patients must consult a physician and apply them under the guidance of the physician, and must not choose their own drugs for treatment.