There is no definite time for how long the condition of renal function stage 4 can be controlled without progressing to uremia, and the condition of each person is different, so it can’t be generalized. It is mainly related to the control of primary disease and symptomatic treatment. 1. Control of primary disease: clinically, there are many causes of renal failure, such as diabetic renal damage, hypertension renal damage, hepatitis B-related nephritis renal damage, chronic glomerulonephritis, etc. Therefore, we must pay attention to the active control of the primary disease, to prevent the further progression of renal failure. 2. Symptomatic treatment: Symptomatic treatment mainly lies in conservative treatment, mainly diuretic swelling, correct anemia, correct calcium and phosphorus metabolism disorders. For diuresis and swelling, furosemide, torasemide and other drugs are mainly used for treatment, renal anemia can be given iron combined with erythropoietin for treatment, and patients with low calcium and high phosphorus can be supplemented with calcium carbonate for treatment. In the clinic for renal failure stage 4 patients to give reasonable treatment, can effectively control the condition, to avoid the development of uremia stage, if there is discomfort, it is recommended to regular hospital nephrology consultation.