Patients with acute allergic reactions should be removed from the sensitizing environment as soon as possible, or the use and intake of sensitizing drugs and substances should be stopped. When the patient shows signs of shock such as decreased blood pressure and poor peripheral circulation, epinephrine should be given subcutaneously or intramuscularly. The drug can not only have a significant blood pressure raising effect and ensure blood perfusion, but also reduce the associated allergic reactions. If the patient is in cardiac or respiratory arrest, cardiopulmonary resuscitation should be performed immediately. In patients with acute allergic reactions, there is often spasm of the airway and edema of the larynx, which can eventually lead to respiratory distress. While giving oxygen therapy, an artificial airway should be established depending on the patient’s condition to ensure the patency of the airway. In addition, glucocorticoids and antihistamines can also be used in the treatment of acute allergic reactions. If the patient’s condition is critical, hemodynamic monitoring should be given to guide fluid resuscitation. At the same time, the patient’s physical examination should be combined with relevant tests to actively prevent the occurrence of brain edema, acidosis and other related complications.