The difference between Irbesartan and Candesartan Ester Tablets mainly lies in the adverse reactions and contraindications of the drugs, and both drugs need to be used under the guidance of a doctor. Irbesartan and candesartan ester tablets both belong to the angiotensin di-receptor inhibitors, which are clinically used to treat essential hypertension and type 2 diabetes mellitus combined with hypertension. The common adverse effects of Irbesartan are dizziness, upright hypotension, nausea, vomiting, fatigue skeletal muscle pain, etc. Irbesartan is contraindicated in the 4th to 9th month of pregnancy and during lactation. The common adverse reactions of candesartan ester tablets are acute renal failure, hyperkalemia, syncope, angioedema, rhabdomyolysis, interstitial pneumonia, etc. It is contraindicated in pregnant women, patients with severe hepatic or renal insufficiency or cholestasis. Both drugs need to strictly follow the doctor’s instructions to standardize the use, the emergence of adverse reactions should be timely medical treatment.