Certain endocrine disorders can cause hypertension, such as hyperthyroidism (hyperthyroidism), Cushing’s syndrome, pheochromocytoma, and primary aldosteronism. Hypertension combined with hypokalemia is a symptomatic feature of these disorders and is one of the diagnostic clues. However, hypertension combined with hypokalemia cannot be directly equated with endocrine hypertension. In fact, in terms of morbidity, hypokalemia is more common in primary hypertension due to overdose of diuretics. Therefore, community physicians who encounter hyperkalemia in hypertensive patients should first ask about medical history and medications rather than blindly referring them to a higher level hospital. Endocrine hypertension usually has a corresponding clinical presentation. For example, hypokalemia may be present in patients with hyperthyroidism combined with periodic paralysis, but the hyperthyroid manifestations are usually more pronounced; Cushing’s syndrome has a characteristic physical appearance and is not difficult to detect; pheochromocytoma is characterized by high and fluctuating blood pressure and manifestations of excessive catecholamine release, such as tachycardia, sweating, abdominal pain and weight loss. These patients should avoid applying B-blockers before lowering blood pressure with Ot-blockers; otherwise, after 13-adrenergic receptors are blocked by drugs and a-receptors are relatively activated, the patient’s blood pressure can further increase and even induce hypertensive emergencies. The manifestation of primary periaqueductinosis is relatively unspecific, but hypokalemia is more persistent and can occur even after discontinuation of diuretics.