A definitive diagnosis of lung nodules is recommended through a pathology biopsy, which can provide a definitive diagnosis of the presence and type of tumor. Pathologic biopsy is recommended for lung nodules that are difficult to diagnose or are suspected of being malignant. Pathological biopsy can be used to make a clear diagnosis of whether there is a tumor or not, and if the diagnosis is confirmed as a tumor, the type of tumor can be made at the same time, and if it is difficult to make a clear morphological classification, immunohistochemical staining can be further performed. Currently, common pathologic biopsy methods include CT-guided percutaneous lung puncture, ultrasound-guided puncture, bronchial puncture biopsy and other measures. The specific method to be chosen needs to be judged by the clinician according to the location of the nodule and other factors. If metastatic lung cancer is suspected, it is recommended to go to the hospital for consultation in time.